Long-term plasticity of hippocampal interneurons during in vivo memory processes
| Autor: | Petrina Yau-Pok Lau, Karri Lamsa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Interneuron General Neuroscience Long-Term Potentiation Hippocampus Biology Hippocampal formation Plasticity 03 medical and health sciences Glutamatergic 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Interneurons Memory In vivo medicine Excitatory postsynaptic potential Animals GABAergic Neuroscience gamma-Aminobutyric Acid 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Neurobiology. 54:20-27 |
| ISSN: | 0959-4388 |
| Popis: | Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnecting principal cells. In addition, recent studies in the hippocampus in vivo indicate that reconfiguration of GABAergic inhibitory interneuron activity also occurs during long-term memory encoding. Recent experiments in anesthetized, as well as in freely moving animals, demonstrate that learning-related hippocampal activities are associated with persistent changes in GABAergic interneuron firing rates and alterations in protein expression levels regulating GABA release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect