Treatment outcomes of multidrug-resistant tuberculosis in Hangzhou, China, 2011 to 2015
| Autor: | Li Xie, Cynthia X. Shi, Han-Zhu Qian, Min Lu, Le Wang, Gang Zhao, Meng Wang, Limin Wu, Qingchun Li, Yifei Wu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China medicine.medical_specialty Tuberculosis Extensively Drug-Resistant Tuberculosis Antitubercular Agents Observational Study Odds extensively drug resistant tuberculosis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Outcome Assessment Health Care medicine Humans 030212 general & internal medicine Young adult retrospective cohort study Aged Retrospective Studies Proportional hazards model business.industry Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease multidrug-resistant tuberculosis Confidence interval 030220 oncology & carcinogenesis treatment outcome Female Observational study business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging. More research is needed to understand treatment outcomes and associated factors. A retrospective cohort study was conducted to assess trends and predictors of treatment success among 398 MDR-TB and extensively drug resistant TB patients who started treatment in 2011 to 2015 in Hangzhou, China. Sociodemographic and clinical characteristic data were obtained from the national reporting database. Chi-square test for trend was used to evaluate changes in treatment success rates over the study years, and Cox regression analysis was used to identify predictors for poor treatment outcomes. The treatment success rate was 76% (301/398) for all participants, 77% (298/387) for MDR-TB cases and 27% (3/11) for extensively drug-resistant tuberculosis -TB cases. Treatment success increased significantly from 66% among patients who started treatment in 2011 to 85% in 2015 (P |
| Databáze: | OpenAIRE |
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