A crosscut survey on reproductive health in Lithuanian childhood cancer survivors
| Autor: | Kestutis Zagminas, Egle Stukaite-Ruibiene, Zivile Gudleviciene, Robertas Adomaitis, Jelena Rascon, Zana Bumbuliene, Mantas Jurkonis, Rasa Vaiciuniene, Gilvydas Verkauskas |
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| Rok vydání: | 2020 |
| Předmět: |
Delayed puberty
Adult Male Pediatrics medicine.medical_specialty Adolescent media_common.quotation_subject late effects long-term survivors pediatric cancer reproductive health sexual dysfunction Fertility Cancer Survivors Neoplasms Surveys and Questionnaires medicine Humans Child Reproductive health media_common Response rate (survey) business.industry Medical record Obstetrics and Gynecology Lithuania Pediatric cancer Sexual dysfunction Reproductive Health Menarche Quality of Life Female medicine.symptom business |
| Zdroj: | Ginekologia polska, Gdańsk : Via Medica, 2021, vol. 92, no. 4, p. 262-270 Ginekologia polska, Gdańsk : Via Medica, 2021, vol. 92, p. [1-9] |
| ISSN: | 2543-6767 0017-0011 |
| Popis: | Objectives: Sexual dysfunction was reported to compromise the quality of life in childhood cancer survivors. The aim of our study was to evaluate the reproductive health in long-term pediatric cancer survivors by conducting a crosscut survey. Material and methods: Childhood cancer survivors over 18 years of age, who were in remission for more than 5 years, were invited to complete a gender-specific questionnaire surveying on their reproductive health. Demographic and treatment data were retrieved from their medical records. Treatment modalities were reviewed for its potential gonadotoxicity. Results: 34 (17 males and 17 females, respectively) from 346 addressed survivors (9.8%) completed the questionnaire. Median age and follow-up after diagnosis was 27 (18–35) and 14 (3–25) years, respectively. Some respondents reported sexual concerns: 11.8% males experienced problems with penetration, two males (11.8%) who underwent semen analysis were found to be azoospermic. Similarly, 11.8% females reported delayed puberty, the average age of menarche was 14 (12–17) years, 29.4% females reported irregular menstrual cycles. Cyclophosphamide equivalent dose (CED) differed significantly between the patients treated for leukemia, lymphoma and solid tumors (3000 vs 4352 vs 6660 mg/m2, respectively, p = 0.014). Conclusions: Low prevalence of sexual dysfunction, fertility related disorders or delayed puberty in childhood cancer survivors was found. However, the results should be interpreted with caution taking into account a low response rate. |
| Databáze: | OpenAIRE |
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