Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation
| Autor: | Jeffrey P. Rasmussen, Eric Peterman, Chang Yin, Jay Z. Parrish |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Neurite Danio Sensory system Neurosciences. Biological psychiatry. Neuropsychiatry Review Somatosensory system 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine epidermis medicine Axon Zebrafish Caenorhabditis elegans axon and dendrite development biology integumentary system somatosensory neuron fungi biology.organism_classification zebrafish 030104 developmental biology medicine.anatomical_structure Cellular Neuroscience C. elegans Drosophila Drosophila melanogaster Neuroscience 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Frontiers in Cellular Neuroscience, Vol 15 (2021) Frontiers in Cellular Neuroscience |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2021.680345/full |
| Popis: | Somatosensory neurons (SSNs) densely innervate our largest organ, the skin, and shape our experience of the world, mediating responses to sensory stimuli including touch, pressure, and temperature. Historically, epidermal contributions to somatosensation, including roles in shaping innervation patterns and responses to sensory stimuli, have been understudied. However, recent work demonstrates that epidermal signals dictate patterns of SSN skin innervation through a variety of mechanisms including targeting afferents to the epidermis, providing instructive cues for branching morphogenesis, growth control and structural stability of neurites, and facilitating neurite-neurite interactions. Here, we focus onstudies conducted in worms (Caenorhabditis elegans), fruit flies (Drosophila melanogaster), and zebrafish (Danio rerio): prominent model systems in which anatomical and genetic analyses have defined fundamental principles by which epidermal cells govern SSN development. |
| Databáze: | OpenAIRE |
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