Comparative pharmacokinetics of verapamil and norverapamil in normal and ulcerative colitis rats after oral administration of low and high dose verapamil by UPLC-MS/MS

Autor:	Hongping Yao, Aiguo Zeng, Changhe Wang, Guangde Yang, Wen Lu, Wen Li, Wanghui Jing, Jiye Zhang
Rok vydání:	2019
Předmět:	Male Metabolic Clearance Rate Health Toxicology and Mutagenesis Administration Oral Pharmacology Toxicology 030226 pharmacology & pharmacy Biochemistry Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Tandem Mass Spectrometry Oral administration Animals Humans Medicine Dextran Sulfate Sodium P-glycoprotein biology business.industry Norverapamil General Medicine Calcium Channel Blockers medicine.disease Ulcerative colitis Rats Verapamil chemistry Area Under Curve 030220 oncology & carcinogenesis biology.protein Colitis Ulcerative Uplc ms ms business Chromatography Liquid medicine.drug
Zdroj:	Xenobiotica. 50:713-721
ISSN:	1366-5928 0049-8254
DOI:	10.1080/00498254.2019.1682715
Popis:	In this study, UC rat model was established by administration of 5% (w/v) dextran sulfate sodium, and the pharmacokinetics of verapamil and norverapamil were evaluated in normal and UC rats using UPLC-MS/MS after oral administration of 5 mg/kg and 50 mg/kg verapamil.The peak concentration (C
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7dbd0bb233ddd615f1cf65bc6294a34 https://doi.org/10.1080/00498254.2019.1682715 Zobrazit plný text záznamu