Apoprotein B, Small‐Dense LDL and Impaired HDL Remodeling Is Associated With Larger Plaque Burden and More Noncalcified Plaque as Assessed by Coronary CT Angiography and Intravascular Ultrasound With Radiofrequency Backscatter: Results From the ATLANTA I Study

Autor: Anna Kalynych, Charles H. Brown, Michael Elashoff, Dimitri Karmpaliotis, Zhen Qian, Jesus G. Vazquez-Figueroa, Sarah Rinehart, Laura Murrieta, Ernst J. Schaefer, Bela F. Asztalos, Hunt Anderson, Szilard Voros, Parag H. Joshi
Rok vydání: 2013
Předmět:
Male
Apolipoprotein B
Coronary Artery Disease
High-Density Lipoproteins
Pre-beta
Coronary Angiography
Coronary artery disease
Intravascular ultrasound
Coronary Heart Disease
Prospective Studies
Original Research
medicine.diagnostic_test
biology
imaging
Coronary ct angiography
Middle Aged
Prognosis
Coronary Vessels
Plaque
Atherosclerotic
Lipoproteins
LDL
Cardiology
Radiographic Image Interpretation
Computer-Assisted
lipids (amino acids
peptides
and proteins)
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Small dense ldl
HDL remodeling
lipids
Necrosis
Imaging
Three-Dimensional
Predictive Value of Tests
Internal medicine
medicine
Humans
Particle Size
Vascular Calcification
Ultrasonography
Interventional
Aged
Apolipoproteins B
business.industry
nutritional and metabolic diseases
medicine.disease
lipoproteins
Stenosis
Cross-Sectional Studies
biology.protein
atherosclerosis
Tomography
X-Ray Computed
business
Biomarkers
Calcification
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
DOI: 10.1161/jaha.113.000344
Popis: Background Apoprotein B–containing lipoproteins are atherogenic, but atheroprotective functions of apoprotein A–containing high‐density lipoprotein ( HDL ) particles are poorly understood. The association between lipoproteins and plaque components by coronary computed tomography angiography ( CTA ) and intravascular ultrasound with radiofrequency backscatter ( IVUS / VH ) has not been evaluated. Methods and Results Quantitative, 3‐dimensional plaque measurements were performed in 60 patients with CTA and IVUS / VH . Apoproteins, lipids, and HDL subpopulations were measured with 2‐dimensional (2D) gel electrophoresis, and correlation was assessed with univariate and multivariable models. ApoB particles were associated with a higher proportion of noncalcified plaque ( NCP ) and a lower proportion of calcified plaque (small, dense low‐density lipoprotein cholesterol and high‐density NCP : r =0.3, P =0.03; triglycerides and low‐density NCP : r =0.34, P =0.01). Smaller, dense, lipid‐poor HDL particles were associated with a shift from calcified plaque to NCP on CTA (α3‐ HDL % and low‐density NCP : r =0.32, P =0.02) and with larger plaque volume on IVUS / VH (α4‐ HDL %: r =0.41, P =0.01; α3‐ HDL %: r =0.37, P =0.03), because of larger dense calcium (α4‐ HDL %: r =0.37, P =0.03), larger fibrous tissue (α4‐ HDL %: r =0.34, P =0.04), and larger necrotic core (α4‐ HDL %: r =0.46, P HDL %: r =0.37, P =0.03). Larger lipid‐rich HDL particles were associated with less low‐density NCP on CTA (α2‐ HDL %: r =−0.34, P =0.02; α1‐ HDL %: r =−0.28, P =0.05), with smaller plaque volume on IVUS / VH (pre‐α2‐ HDL : r =−0.33, P =0.05; α1‐ HDL %: r =−0.41, P =0.01; pre‐α2‐ HDL : r =−0.33, P =0.05) and with less necrotic core (α1‐ HDL : r =−0.42, P HDL : r =−0.38, P =0.02; α2‐ HDL : r =−0.35, P =0.03; pre‐α1‐ HDL : r =−0.34, P =0.04). Pre‐β2‐ HDL was associated with less calcification and less stenosis by both modalities. Conclusions ApoB and small HDL particles are associated with larger plaque burden and more noncalcified plaque, whereas larger HDL and pre‐β2‐ HDL particles are associated with plaque burden and less noncalcified plaque by both CTA and IVUS / VH .
Databáze: OpenAIRE
Externí odkaz: