Decreased expression of natriuretic peptide a receptors and decreased cGMP production in the choroid plexus of spontaneously hypertensive rats
| Autor: | Juan M. Saavedra, Angela Alsasua, Stefan Zorad |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Rats Inbred WKY Second Messenger Systems chemistry.chemical_compound Rats Inbred SHR Internal medicine Cyclic AMP medicine Natriuretic peptide Animals Receptor Cyclic GMP Molecular Biology Forskolin Chemistry General Neuroscience NPR1 NPR2 Rats Endocrinology Guanylate Cyclase Choroid Plexus Hypertension cardiovascular system Autoradiography Choroid plexus Neurology (clinical) Signal transduction Atrial natriuretic peptide receptor Receptors Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Molecular and Chemical Neuropathology. 33:209-222 |
| ISSN: | 1044-7393 |
| DOI: | 10.1007/bf02815183 |
| Popis: | Atrial natriuretic peptide receptor (ANP) subtypes and their signal transduction response were characterized in choroid plexus of spontaneously hypertensive (SHR) and normotensive (WKY) rats. We found two ANP receptor subtypes, guanylate cyclase coupled and uncoupled, in both rat strains. Binding of ANP was lower in SHR choroid plexus when compared to WKY. The lower ANP binding in SHR was the result of a decrease of binding to the guanylate cyclase-coupled receptor subtype A, a decrease that correlated well with the decreased ANP-induced cGMP formation in SHR. Forskolin stimulated cGMP production to the same extent in both strains. In WKY rats, ANP increased basal and forskolin-stimulated cAMP production; conversely, in SHR, ANP did not affect the basal level of cAMP and inhibited the forskolin-stimulated cAMP production. These results demonstrate differences in ANP receptor subtype expression, and ANP signal transduction in choroid plexus of hypertensive and normotensive rats, which is of possible significance to the central mechanisms of blood pressure control. |
| Databáze: | OpenAIRE |
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