Circulating long noncoding RNA, GAS5, as a novel biomarker for patients with atrial fibrillation

Autor: Leiyang Chen, Bifeng Wu, Jiaran Shi, Shi Chen, Kun Yang, Xiaosheng Hu
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Clinical Biochemistry
radiofrequency catheter ablation
03 medical and health sciences
lncRNA
0302 clinical medicine
Internal medicine
Atrial Fibrillation
GAS5
Left atrial enlargement
Humans
Immunology and Allergy
Medicine
Research Articles
Aged
Receiver operating characteristic
business.industry
Proportional hazards model
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Atrial fibrillation
Hematology
Middle Aged
Prognosis
medicine.disease
Long non-coding RNA
Medical Laboratory Technology
030104 developmental biology
Radiofrequency catheter ablation
030220 oncology & carcinogenesis
Catheter Ablation
Cardiology
biomarker
Biomarker (medicine)
Female
RNA
Long Noncoding
business
Biomarkers
Research Article
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
DOI: 10.1002/jcla.23572
Popis: Background Circulating long noncoding RNA (lncRNA) plays a vital role in clinical disease diagnosis and prognosis. Here, we evaluate the role of a lncRNA, named growth arrest specific 5 (GAS5), in atrial fibrillation (AF). Methods Expression of GAS5 was measured by qRT‐PCR. Diagnostic and prognostic values of GAS5 were assessed by the receiver operating characteristics curve (ROC), Kaplan–Meier (KM) and Cox regression analyses. Results A total of 173 participants were enrolled in this study. Circulating GAS5 expression was significantly down‐regulated in AF patients. This change occurred prior to enlargement of the left atrial volume and was strongly associated with AF progression, which demonstrates the potential use of GAS5 as an early biomarker. The area under the ROC curve (AUC) was 0.858 (95% CI 0.789‐0.926, P
In this work, we identified the role of long noncoding RNA Growth arrest specific 5 (GAS5) as a novel biomarker for AF diagnosis and prognosis. Firstly, the remarkable downregulation of circulating GAS5 level in AF patients was found. Satisfactory sensitivity, specificity and positive predictive value of GAS5 to diagnose AF were further proved. Moreover, its downregulation was prior to enlargement of left atrial and strongly associated with AF progression. Finally, GAS5 was regarded as an independent predictor of AF recurrence during 3‐12 months after catheter ablation.
Databáze: OpenAIRE
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