Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke
Autor: | Wenmin Feng, Jincheng Liu, Lingyun Wang, Yan Shen, Lijun Wang, Peiyang Zhou, Wang-Yang Xu, Zhihua Cao, Jinbo Yang, Peng Meng, Gao Ping |
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Rok vydání: | 2020 |
Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry 030204 cardiovascular system & hematology Logistic regression Carotid Intima-Media Thickness Brain Ischemia 0302 clinical medicine Endocrinology Risk Factors Independent risk factor 030212 general & internal medicine lcsh:RC620-627 Stroke education.field_of_study Acute ischaemic stroke risk Carotid ultrasonography Middle Aged Prognosis musculoskeletal system Carotid plaque Plaque Atherosclerotic lcsh:Nutritional diseases. Deficiency diseases Carotid Arteries cardiovascular system Cardiology Female Lipidology Adult medicine.medical_specialty Logistic regression model Population Clinical nutrition 03 medical and health sciences Internal medicine medicine Humans cardiovascular diseases Risk factor education Triglycerides Small dense low-density lipoprotein cholesterol Ischemic Stroke Retrospective Studies business.industry Research Biochemistry (medical) Cholesterol LDL Atherosclerosis medicine.disease Intima media thickness Logistic Models Intima-media thickness business |
Zdroj: | Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-10 (2020) Lipids in Health and Disease |
ISSN: | 1476-511X |
Popis: | Background Intima-media thickness (IMT) and small dense low-density lipoprotein cholesterol (sdLDL-C) have been reported to be related to atherosclerosis and stroke. This study is trying to explore the association between IMT and sdLDL-C in Chinese acute ischaemic stroke (AIS) subjects. Methods This study enrolled total 368 consecutive AIS patients and 165 non-AIS controls from November 2016 to February 2019. Mean IMT and carotid plaques were measured by using carotid ultrasonography method. Blood glucose and lipid parameters were measured by using an automatic biochemical instrument. SdLDL-C was detected by using the Lipoprint LDL system. IMT > 1.0 mm was defined as increased IMT. Plaque stability based on the nature of the echo was determined by ultrasound examination. Risk factors for IMT were identified by using multivariate logistic regression analysis. A logistic regression model was established to predict AIS risk. Python software (Version 3.6) was used for the statistical analysis of all data. Results The carotid IMT, proportion of plaques, and the sdLDL-C, triglycerides (TG) and glucose levels were obviously higher in AIS patients than those in controls. SdLDL-C level in the IMT thickening group was higher than that in the normal IMT group. SdLDL-C and total cholesterol (TC) were risk factors for IMT, while sdLDL-C was an independent risk factor. The IMT value of the unstable plaque group was markedly higher than that of the stable plaque group. The predictive value of IMT for AIS was better than that of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) but not as good as that of sdLDL-C. A logistic regression model was established to predict AIS risk. Additionally, carotid IMT and sdLDL-C were closely related to AIS severity and outcomes. Conclusions SdLDL-C and TC were risk factors for increased IMT, while sdLDL-C was an independent risk factor. A prediction model based on IMT and other variables was established to screen the population with high AIS risk. |
Databáze: | OpenAIRE |
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