Seizures associated with ofloxacin therapy
| Autor: | Mark F. Bonfiglio, James A. Wilson, Nicholas A. Nackes, Bradley R. Martin, Sheldon M. Traeger |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Neurotoxicity Syndrome Ofloxacin Haemophilus Infections medicine.drug_class Antibiotics Central nervous system disease Epilepsy Seizures Internal medicine medicine Humans Aged Related factors Aged 80 and over business.industry Pneumonia Middle Aged medicine.disease Haemophilus influenzae Surgery Klebsiella Infections Regimen Klebsiella pneumoniae Infectious Diseases Toxicity Female business medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 21(6) |
| ISSN: | 1058-4838 |
| Popis: | We describe four patients who had seizures while receiving ofloxacin ; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor. Other potentially related factors included electrolyte abnormalities and prior neurological insult. Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use. |
| Databáze: | OpenAIRE |
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