Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

Autor: Mariusz Grzesiak, Wioletta Wujcicka, Piotr Kaczmarek, Marian Kacerovsky, Michał Krekora
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
medicine.medical_specialty
Fetal Membranes
Premature Rupture
Lipoproteins
Population
Single-nucleotide polymorphism
Prom
QH426-470
Gastroenterology
Polymorphism
Single Nucleotide
Article
angiogenesis
Young Adult
single nucleotide polymorphism (SNP)
Pregnancy
Internal medicine
Genotype
Genetics
medicine
Rupture of membranes
Humans
pPROM
Genetic Predisposition to Disease
education
Genotyping
tPROM
Genetics (clinical)
Genetic Association Studies
education.field_of_study
Vascular Endothelial Growth Factor Receptor-1
business.industry
Granulocyte-Macrophage Colony-Stimulating Factor
medicine.disease
female genital diseases and pregnancy complications
genotyping
Hemostasis
Case-Control Studies
Toll-Like Receptor 9
hemostasis
Female
prelabor rupture of membranes (PROM)
business
restriction fragment length polymorphism (RFLP)
Maternal Age
Zdroj: Genes
Volume 12
Issue 11
Genes, Vol 12, Iss 1725, p 1725 (2021)
ISSN: 2073-4425
Popis: A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in CSF2 (rs25881), FLT1 (rs722503), TFPI (C-399T) and TLR9 (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for CSF2 and FLT1 polymorphisms, CC variants for TLR9 and TFPI SNPs, TTC for CSF2, FLT1 and TLR9 polymorphisms, TTT for FLT1, TLR9 and TFPI SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the CSF2, FLT1 and TLR9 SNPs and the CCTC for the CSF2, FLT1, TLR9 and TFPI polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.
Databáze: OpenAIRE
Externí odkaz: