Local Expression of Mucosal YKL-40; Correlation of YKL-40 with Clinical Manifestations and Immunopathogenesis of Moderate/Severe Persistent Allergic Rhinitis Patients
| Autor: | Hamid Reza Khazraei, Hedayatollah Shirzad, Omid Zargari Samani, Mandana Moghni, Zahra Noormohammadian, Nader Bagheri, Ashkan Pirayesh, Mohammad Ali Zamani, Shaghayegh Shahsavan, Farbod Torkamand, Fatemeh Deris, Soroush Amani |
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| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Adult Male Immunology Inflammation Disease Immunoglobulin E law.invention Correlation 03 medical and health sciences 0302 clinical medicine law medicine Humans In patient Chitinase-3-Like Protein 1 Polymerase chain reaction biology business.industry General Medicine Eosinophil Rhinitis Allergic Nasal Mucosa 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Immunohistochemistry Female medicine.symptom business |
| Zdroj: | Immunological investigations. 49(1-2) |
| ISSN: | 1532-4311 |
| Popis: | YKL-40 is an important protein that plays a critical role in chronic inflammation in hypersensitivity disease. In this study, the expression of YKL-40 was investigated among patients with moderate/severe persistent allergic rhinitis (M/S PAR), patients with mild (M) PAR and healthy individuals. Moreover, the association between YKL-40 and immunopathogenesis of M/S PAR was meticulously surveyed. For this purpose, surgical samples were tested by real-time polymerase chain reaction to evaluate YKL-40 mRNA expression. The presence and location of YKL-40 protein in the tissue samples were determined by immunohistochemistry. Additionally, we measured the number of eosinophils per field in the tissue samples, blood eosinophils, total serum IgE, specific serum IgE, total nasal syndrome score (TNSS) and YKL-40 serum levels. The data indicated that production of YKL-40 in patients with M/S PAR increased significantly when compared with the control group. Furthermore, local production of YKL-40 correlated with specific IgE, nasal eosinophil count and TNSS. The results of the present study indicate that YKL-40, for its correlation with allergic clinical manifestations and symptom severity in M/S PAR patients, should be considered as a trigger factor in AR. |
| Databáze: | OpenAIRE |
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