Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort

Autor:	Phabiola Herrera, Romina E. Aragón, Nicole Mongilardi, Enrique Paz, Eduardo E. Chirinos, Roy G. Brower, Jose Portugal, Aldo De Ferrari, Rocio Quispe, Alvaro Proaño, Rollin Roldan, Amador A. Jaymez, William Checkley
Rok vydání:	2019
Předmět:	Male Conscious Sedation clinical outcome mortality rate Richmond Agitation-Sedation Scale Critical Care and Intensive Care Medicine intensive care unit haloperidol law.invention Cohort Studies 0302 clinical medicine Interquartile range law Clinical outcomes middle aged Peru Odds Ratio Hypnotics and Sedatives Longitudinal Studies Prospective Studies Richmond Agitation Sedation Scale APACHE benzodiazepine derivative Aged 80 and over Analgesics Cumulative dose adult lcsh:Medical emergencies. Critical care. Intensive care. First aid longitudinal study dexmedetomidine artificial ventilation Middle Aged cohort analysis ventilated patient Intensive care unit 3. Good health anesthesia level Intensive Care Units Treatment Outcome female agitation priority journal sedation Sedation Anesthesia Female medicine.symptom Propofol Antipsychotic Agents prospective study medicine.drug Adult prevalence Ramsay Sedation Scale Article 03 medical and health sciences critically ill patient narcotic analgesic agent length of stay male Intensive care medicine Humans Sequential Organ Failure Assessment Score controlled study human Dexmedetomidine Aged drug use acute respiratory failure propofol business.industry Research public hospital Glasgow coma scale 030208 emergency & critical care medicine lcsh:RC86-88.9 clinical assessment Respiration Artificial major clinical study Logistic Models multicenter study deep sedation mortality risk observational study Deep Sedation Neuromuscular Blocking Agents Critical illness business purl.org/pe-repo/ocde/ford#3.02.09 [https]
Zdroj:	Critical Care Critical Care, Vol 23, Iss 1, Pp 1-9 (2019)
ISSN:	1364-8535
DOI:	10.1186/s13054-019-2394-9
Popis:	Objectives We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting. Design A longitudinal study of critically ill participants on mechanical ventilation. Setting Five intensive care units (ICUs) in four public hospitals in Lima, Peru. Patients One thousand six hundred fifty-seven critically ill participants were assessed daily for sedation status during 28 days and vital status by day 90. Results After excluding data of participants without a Richmond Agitation Sedation Scale score and without sedation, we followed 1338 (81%) participants longitudinally for 18,645 ICU days. Deep sedation was present in 98% of participants at some point of the study and in 12,942 ICU days. Deep sedation was associated with higher mortality (interquartile odds ratio (OR) = 5.42, 4.23–6.95; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b723c376f64951ea7e506912b939f2b8 https://doi.org/10.1186/s13054-019-2394-9 Zobrazit plný text záznamu Full text from SpringerLink