Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice
| Autor: | Steve Kaufman, S. Scully, Karen Rex, C. R. Dipalma, Catherine L. Farrell, David L. Lacey, J. N. Chen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Fibroblast Growth Factor 7 Ratón Stratified squamous epithelium Biology Mice chemistry.chemical_compound Esophagus Tongue medicine Animals Radiology Nuclear Medicine and imaging RNA Messenger Growth Substances Mice Inbred BALB C Radiological and Ultrasound Technology Cell growth Mouth Mucosa Total body irradiation Epithelium Fibroblast Growth Factors medicine.anatomical_structure Palifermin chemistry Female Keratinocyte growth factor Fibroblast Growth Factor 10 Whole-Body Irradiation medicine.drug |
| Zdroj: | International Journal of Radiation Biology. 75:609-620 |
| ISSN: | 1362-3095 0955-3002 |
| DOI: | 10.1080/095530099140258 |
| Popis: | To investigate the effects of keratinocyte growth factor (KGF) on the structure of the stratified squamous epithelium of the tongue, buccal mucosa and oesophagus of normal and irradiated mice.Female BDF1 mice were exposed to total body irradiation from a caesium source. The irradiated mice and normal, unirradiated mice were injected with 5 mg/kg per day KGF or vehicle. Thickness and proliferation in the epithelium were measured.KGF caused epithelial thickening of the non-keratinized layers in oral epithelium in normal mice. It increased the number of nucleated layers and influenced differentiation of post-mitotic cells in the upper layers by increasing the size and number of keratohyalin granules, and the number of desmosomes. Single and fractionated doses of radiation caused inhibition of proliferation as detected by markedly reduced BrdU incorporation following exposure, followed by epithelial atrophy. KGF treatment of mice reversed the inhibition of proliferation and atrophy that occurred in control irradiated mice.These data show that KGF reverses epithelial atrophy in mouse oral cavity caused by irradiation and suggest that KGF may be useful for the treatment of mucositis of the upper aerodigestive tract of patients treated with aggressive regimens of radiation therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|