Virus population homogenization following acute human immunodeficiency virus type 1 infection
| Autor: | Kurt Diem, Lawrence Corey, Gerald H. Learn, James I. Mullins, Tuofu Zhu, Scott J. Brodie, David Muthui |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Time Factors HIV Antigens viruses Immunology Population Molecular Sequence Data Virulence Gene Products gag Viremia HIV Infections Biology HIV Envelope Protein gp120 Microbiology Genes env gag Gene Products Human Immunodeficiency Virus Virus Evolution Molecular Viral Proteins Acquired immunodeficiency syndrome (AIDS) Phylogenetics Virology medicine Humans Homosexuality Male Selection Genetic education Gene Phylogeny education.field_of_study Base Sequence virus diseases medicine.disease Genes gag Insect Science Acute Disease DNA Viral HIV-1 Pathogenesis and Immunity |
| Zdroj: | Journal of virology. 76(23) |
| ISSN: | 0022-538X |
| Popis: | Understanding the properties of human immunodeficiency virus type 1 (HIV-1) variants capable of establishing infection is critical to the development of a vaccine against AIDS. Previous studies of men have shown that the HIV-1 env gene is homogeneous early in infection, leading to the suggestion that infection is established by a single transmitted variant. However, we report here that all of eight homosexual men evaluated beginning 3.7 to 9 weeks following onset of symptoms of acute infection harbored diverse virus populations in their blood, with median genetic distances averaging 1.08% in the env C2V5 region and 0.81% in the gag p17 gene. Within another 4.7 to 11 weeks, the variant lineage in env became more homogeneous, while gag sequences continued to diversify. Thus, the homogenization that has been reported to characterize acute infection is actually preceded by the replication of multiple virus variants. This early selective process focuses on viral properties within Env but not Gag p17. Hence, the viral homogeneity observed early in HIV-1 infection results from a selective process that occurs during the establishment of infection. |
| Databáze: | OpenAIRE |
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