Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds

Autor:	Tsuneo, Omura
Rok vydání:	2022
Předmět:	Mammals Pharmacology Cytochrome P-450 Enzyme System Liver Enzyme Induction Microsomes Liver Animals Pharmaceutical Science Xenobiotics
Zdroj:	Drug Metabolism and Disposition. 50:1000-1001
ISSN:	1521-009X 0090-9556
DOI:	10.1124/dmd.122.000891
Popis:	The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to investigate this induction mechanism. Currently, the mechanisms mediated by aryl hydrocarbon receptor and constitutive androstane receptor are well-established. In addition to mammals, insects and fungi also express P450s and induce them following exposure to insecticides. These inductions may have environmental consequences. Finding the molecular mechanism regulating these inductions will be of major interest in the future. SIGNIFICANCE STATEMENT: This paper summarizes present and future of investigations into induction of drug-metabolizing enzymes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b704c48fb23b714678ad9f01c79644b6 https://doi.org/10.1124/dmd.122.000891 Zobrazit plný text záznamu