Antimicrobial and DNA Cleavage Studies of New N2O2Diazadioxa Macrocyclic Schiff Base Co(II), Ni(II) and Cu(II) Complexes Containing Triazole Head Unit: Synthesis and Spectroscopic Approach
| Autor: | Sangamesh A. Patil, Prema S. Badami, Udaykumar V. Kamble |
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| Rok vydání: | 2010 |
| Předmět: |
Schiff base
biology Polymers and Plastics Stereochemistry Chemistry Aspergillus niger Triazole Aspergillus flavus General Chemistry biology.organism_classification medicine.disease_cause Chemical synthesis chemistry.chemical_compound Polymer chemistry Agarose gel electrophoresis medicine Materials Chemistry Ceramics and Composites Escherichia coli Antibacterial agent |
| Zdroj: | Journal of Macromolecular Science, Part A. 47:816-827 |
| ISSN: | 1520-5738 1060-1325 |
| Popis: | A novel series of N2O2 diazadioxa macrocyclic complexes [MLCl2] (M=Co2+, Ni2+ and Cu2+) have been synthesized with newly derived biologically active ligands (LI-LIV). These ligands were synthesized by the condensation of 1, 6-bis(2-formylphenyl)hexane and 3-subtituted-4-amino-5-hydrazino-1, 2, 4-triazole. The mode of bonding and overall geometry of the complexes have been inferred through IR, EPR, electronic spectral studies, conductivity, magnetic, thermal and electrochemical studies. All the complexes are soluble in DMF and DMSO and are non-electrolytes. All these complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by the MIC method. The DNA cleavage study was done by Agarose gel electrophoresis. |
| Databáze: | OpenAIRE |
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