EFFECTS OF TRAMADOL ON THE MINIMUM ANESTHETIC CONCENTRATION OF ISOFLURANE IN WHITE-EYED PARAKEETS (PSITTACARA LEUCOPHTHALMUS)
| Autor: | Karin Werther, Rozana Wendler da Rocha, André Escobar, Darcio Zangirolami Filho, Monica Midon, Ricardo Almeida |
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| Rok vydání: | 2017 |
| Předmět: |
040301 veterinary sciences
Psittacara leucophthalmus medicine.medical_treatment 0403 veterinary science 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Animals Drug Interactions Tramadol Mechanical ventilation General Veterinary Dose-Response Relationship Drug Isoflurane business.industry Parakeets 04 agricultural and veterinary sciences General Medicine Anesthesia Anesthetic Anesthetics Inhalation Animal Science and Zoology business Anesthesia Inhalation medicine.drug |
| Zdroj: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 48(2) |
| ISSN: | 1042-7260 |
| Popis: | The aim of this study was to determine the minimum anesthetic concentration (MAC) of isoflurane, and to investigate if tramadol changes the isoflurane MAC in white-eyed parakeets (Psittacara leucophthalmus). Ten adult birds weighing 157 ± 9 g were anesthetized with isoflurane in oxygen under mechanical ventilation. Isoflurane concentration for the first bird was adjusted to 2.2%, and after 15 min an electrical stimulus was applied in the thigh area to observe the response (movement or nonmovement). Isoflurane concentration for the subsequent bird was increased by 10% if the previous bird moved, or decreased by 10% if the previous bird did not move. This procedure was performed serially until at least four sequential crossover events were detected. A crossover event was defined as a sequence of two birds with different responses (positive or negative) to the electrical stimulus. Isoflurane MAC was calculated as the mean isoflurane concentration value at the crossover events. After 1 wk, the same birds were reanesthetized with isoflurane and MAC was determined at 15 and 30 min after intramuscular administration of 10 mg/kg of tramadol using the same method. A paired t-test (P0.05%) was used to detect significant differences for MAC between treatments. Isoflurane MAC in this population of white-eyed parakeets was 2.47 ± 0.09%. Isoflurane MAC values 15 and 30 min after tramadol administration were indistinguishable from each other (pooled value was 2.50 ± 0.18%); they were also indistinguishable from isoflurane MAC without tramadol. The isoflurane MAC value in white-eyed parakeets is higher than reported for other bird species. Tramadol (10 mg/kg, i.m.) does not change isoflurane MAC in these birds. |
| Databáze: | OpenAIRE |
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