Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma
| Autor: | Edward K. L. Chan, Eric S. Sobel, Westley H. Reeves, T T Webb, M Vázquez-Del Mercado, Malgorzata E. Krzyszczak, Rufus W Burlingame, Minoru Satoh, Yi Li, Angela Ceribelli |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty genetic processes Immunofluorescence Article Scleroderma RNA polymerase III Ribonucleoprotein U1 Small Nuclear Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Autoantibodies Scleroderma Systemic Lupus erythematosus biology medicine.diagnostic_test business.industry Autoantibody RNA Polymerase III Overlap syndrome medicine.disease enzymes and coenzymes (carbohydrates) Antibodies Antinuclear Immunology health occupations biology.protein bacteria Female Antibody business |
| Zdroj: | Lupus. 21:68-74 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203311422712 |
| Popis: | Anti-RNA polymerase III (RNAP III) antibodies are highly specific for scleroderma (SSc) and associated with diffuse SSc and renal crisis. Coexistence of anti-RNAP III and other SSc autoantibodies is rarely documented. We report three cases with coexisting anti-RNAP III and anti-U1RNP. Autoantibodies in 3829 sera from rheumatology clinics were screened by immunoprecipitation. Anti-RNAP III-positive sera were also examined by immunofluorescence and anti-RNAP III ELISA. In total, 35 anti-RNAP III-positive sera were identified by immunoprecipitation, in which three had coexisting anti-U1RNP. All three were anti-RNAP III ELISA positive. Two had anti-RNAP I dominant (vs. RNAP III) reactivity and showed strong nucleolar staining. A case with anti-U1/U2RNP (U2RNP dominant) had systemic lupus erythematosus (SLE)–SSc overlap syndrome; however, the remaining two cases had SLE without signs of SSc. All three cases of anti-RNAP III + U1RNP fulfilled ACR SLE criteria but none in the group with anti-RNAP III alone ( p = 0.0002). In contrast, only one case in the former group had sclerodermatous skin changes and Raynaud's phenomenon, vs. 92% with scleroderma in the latter ( p |
| Databáze: | OpenAIRE |
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