Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels
| Autor: | Saša Peter, Chris I. De Zeeuw, Negah Rahmati, Freek E. Hoebeek |
|---|---|
| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chloride transporters and channels cerebellar motor learning chloride homeostasis Olivocerebellar system Cell volume Review Neurotransmission lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Glycine receptor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry GABAergic inhibition Chemistry Chloride transporters and channels Transporter Chloride homeostasis olivocerebellar system 030104 developmental biology GABAergic Cerebellar motor learning Neuroscience 030217 neurology & neurosurgery Intracellular Function (biology) Homeostasis |
| Zdroj: | Frontiers in Cellular Neuroscience, Vol 12 (2018) Frontiers in Cellular Neuroscience [E], 12. Frontiers Research Foundation Frontiers in Cellular Neuroscience, 12:101. Frontiers Media SA Frontiers in Cellular Neuroscience, 12:101. Frontiers Media S.A. Frontiers in Cellular Neuroscience |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2018.00101/full |
| Popis: | The intraneuronal ionic composition is an important determinant of brain functioning. There is growing evidence that aberrant homeostasis of the intracellular concentration of Cl- ([Cl-]i) evokes, in addition to that of Na+ and Ca2+, robust impairments of neuronal excitability and neurotransmission and thereby neurological conditions. More specifically, understanding the mechanisms underlying regulation of [Cl-]i is crucial for deciphering the variability in GABAergic and glycinergic signaling of neurons, in both health and disease. The homeostatic level of [Cl-]i is determined by various regulatory mechanisms, including those mediated by plasma membrane Cl- channels and transporters. This review focuses on the latest advances in identification, regulation and characterization of Cl- channels and transporters that modulate neuronal excitability and cell volume. By putting special emphasis on neurons of the olivocerebellar system, we establish that Cl- channels and transporters play an indispensable role in determining their [Cl-]i and thereby their function in sensorimotor coordination. |
| Databáze: | OpenAIRE |
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