High-frequency oscillation during simulated altitude exposure
| Autor: | Patricia A. Land, Alan T. Aquilina, Alan R. Saltzman, Neel B. Ackerman, Robert A. Klocke, Brydon J. B. Grant |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Functional Residual Capacity Partial Pressure medicine.medical_treatment High-Frequency Ventilation chemistry.chemical_element Oleic Acids Lung injury Critical Care and Intensive Care Medicine Oxygen law.invention Dogs Animal science Altitude Functional residual capacity law Tidal Volume medicine Animals Cardiac Output Tidal volume Respiratory Distress Syndrome Pulmonary Gas Exchange business.industry High-frequency ventilation Surgery Atmospheric Pressure chemistry Ventilation (architecture) business Oleic Acid |
| Zdroj: | Critical Care Medicine. 18:1257-1260 |
| ISSN: | 0090-3493 |
| Popis: | Ventilatory requirements using high-frequency oscillation (HFO) during simulated altitude exposure were investigated in control dogs and animals with oleic acid-induced lung injury. FIO2 values of 0.21 and 1.0 were supplied by bias flow to the normal and injured dogs, respectively. After a control period, animals were exposed to a simulated altitude of 8,000 ft (barometric pressure 564 torr), followed by a second control period at ground level. Both experimental groups had similar values of PaCO2 at ground level and during exposure to reduced barometric pressure. The tidal volume necessary to maintain eucapnia was higher in oleic acid-injured animals compared with the control group; cardiac output and functional residual capacity were lower. The alveolar-arterial oxygen difference was substantially larger in the oleic acid group. Adequate gas exchange can be maintained with HFO during exposure to altitude provided that ventilation and inspired PO2 are not reduced below normobaric levels. |
| Databáze: | OpenAIRE |
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