Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons
| Autor: | Marcio V. Damico, Erika Reime Kinjo, Erica de Sousa, Luiz R.G. Britto, Alexandre Hiroaki Kihara, Edgard Morya, Guilherme Shigueto Vilar Higa, Bianca Araújo dos Santos, Angela C. Valle, Lais Takata Walter |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male RNA Stability Hippocampus Hippocampal formation Biology Bioinformatics Epileptogenesis Article 03 medical and health sciences 0302 clinical medicine Status Epilepticus Interneurons Seizures microRNA Gene expression medicine Animals GABAergic Neurons Rats Wistar Regulation of gene expression Neurons mRNA Cleavage and Polyadenylation Factors Multidisciplinary Pilocarpine Cell biology FISIOLOGIA MicroRNAs 030104 developmental biology Parvalbumins nervous system Gene Expression Regulation Organ Specificity Exoribonucleases Calretinin 030217 neurology & neurosurgery medicine.drug Subcellular Fractions |
| Zdroj: | Scientific Reports Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep20969 |
| Popis: | Epileptogenesis in the temporal lobe elicits regulation of gene expression and protein translation, leading to reorganization of neuronal networks. In this process, miRNAs were described as being regulated in a cell-specific manner, although mechanistics of miRNAs activity are poorly understood. The specificity of miRNAs on their target genes depends on their intracellular concentration, reflecting the balance of biosynthesis and degradation. Herein, we confirmed that pilocarpine application promptly ( |
| Databáze: | OpenAIRE |
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