Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
| Autor: | Sachiko Yamaguchi, Hajime Suto, Yasuharu Abe, Susumu Nakae, Ayako Takamori, Sachiko Hirose, Tadashi Yokosuka, Aya Nambu, Katsuko Sudo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Autoimmune disease business.industry Innate lymphoid cell Biophysics Arthritis Interleukin medicine.disease Biochemistry lcsh:Biochemistry 03 medical and health sciences 030104 developmental biology Interleukin 1 receptor antagonist Immune system lcsh:Biology (General) Interleukin 25 Immunology Medicine lcsh:QD415-436 business Receptor lcsh:QH301-705.5 Research Article |
| Zdroj: | Biochemistry and Biophysics Reports Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 62-65 (2017) |
| ISSN: | 2405-5808 |
| Popis: | Interleukin (IL)-25, which is a member of the IL-17 family of cytokines, induces production of such Th2 cytokines as IL-4, IL-5, IL-9 and/or IL-13 by various types of cells, including Th2 cells, Th9 cells and group 2 innate lymphoid cells (ILC2). On the other hand, IL-25 can suppress Th1- and Th17-associated immune responses by enhancing Th2-type immune responses. Supporting this, IL-25 is known to suppress development of experimental autoimmune encephalitis, which is an IL-17-mediated autoimmune disease in mice. However, the role of IL-25 in development of IL-17-mediated arthritis is not fully understood. Therefore, we investigated this using IL-1 receptor antagonist-deficient (IL-1Ra-/-) mice, which spontaneously develop IL-17-dependent arthritis. However, development of spontaneous arthritis (incidence rate, disease severity, proliferation of synovial cells, infiltration of PMNs, and bone erosion in joints) and differentiation of Th17 cells in draining lymph nodes in IL-25-/- IL-1Ra-/- mice were similar to in control IL-25+/+ IL-1Ra-/- mice. These observations indicate that IL-25 does not exert any inhibitory and/or pathogenic effect on development of IL-17-mediated spontaneous arthritis in IL-1Ra-/- mice. Highlights • IL-25 is known to inhibit Th17 cell differentiation. • IL-25 is known to suppress Th17-mediated autoimmune diseases in mice. • IL-25 does not play any inhibitory and/or pathogenic role in IL-17-mediated arthritis. |
| Databáze: | OpenAIRE |
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