Protective role of selenium in the shortening of telomere length in newborns induced by in utero heavy metal exposure
| Autor: | Chiho Watanabe, Kyi Mar Wai, Mitsutoshi Umemura, Ohn Mar, Masahiro Umezaki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_element
Myanmar 010501 environmental sciences 01 natural sciences Biochemistry Umbilical cord Metal Andrology Cohort Studies 03 medical and health sciences Selenium 0302 clinical medicine Pregnancy Metals Heavy medicine Humans 030212 general & internal medicine Inductively coupled plasma mass spectrometry Arsenic Telomere Shortening 0105 earth and related environmental sciences General Environmental Science Cadmium Infant Newborn Telomere medicine.disease medicine.anatomical_structure chemistry In utero visual_art visual_art.visual_art_medium Female |
| Zdroj: | Environmental research. 183 |
| ISSN: | 1096-0953 |
| Popis: | The effects of toxic heavy metals, such as arsenic (As), cadmium (Cd), and lead (Pb), on telomere length (TL) have been reported previously. Although selenium (Se) is considered as an anti-oxidant which may detoxify the effects, there are no data on whether Se could protect against the TL-shortening effects of heavy metals. Thus, the aim of this study was to evaluate the protective role of Se against heavy metal-induced TL shortening. A birth cohort study was conducted in Myanmar in 2016, including 408 mother-infant pairs. First, pregnant women in the third trimester were interviewed concerning their socioeconomic, and pregnancy and birth characteristics using a pre-validated questionnaire. Maternal spot urine samples were collected after the interview. During the follow-up period (1–3 months), blood samples were collected from the umbilical cord at birth by local health workers. Metal concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS). TL was measured by quantitative real-time polymerase chain reaction (PCR). Relative TL was calculated as the ratio of telomere genes to single-copy genes. To evaluate the effect of Se on TL shortening, molar ratios were calculated. Linear regression analyses were performed to examine the associations between heavy metals and TL, individually and after adjustment for Se level. The effects of As, Cd, and Pb exposure on TL were smaller after adjustment for the Se level, especially for Pb (unadjusted β = −0.10; 95% CI: 0.18, −0.01; adjusted β = −0.03; 95% CI: 0.13, 0.05). On stratifying the data by Se concentration, there was no significant association between Cd or Pb exposure and TL in the high-Se group. Our study indicated a protective effect of Se against the TL shortening induced by heavy metal exposure, where the effect sizes were smaller after adjusting for the Se level, compared to individual metal exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect