Solid-state photocrosslinking of hyaluronan microfibres
| Autor: | Robert Pospisil, Jiří Běťák, Veronika Chadimová, Tomáš Bobula, Pavel Klein, Radovan Buffa, Martina Moravcová, Ondřej Židek, Vladimír Velebný |
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| Rok vydání: | 2014 |
| Předmět: |
Polymers and Plastics
Ultraviolet Rays Acylation Mice Ultraviolet visible spectroscopy Tensile Strength Polymer chemistry Ultimate tensile strength Materials Chemistry Animals Fourier transform infrared spectroscopy Hyaluronic Acid chemistry.chemical_classification Aqueous solution Viscosity Organic Chemistry Polymer 3T3 Cells Fibroblasts Cross-Linking Reagents chemistry Chemical engineering Solubility Phototoxicity Crystallization Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Carbohydrate polymers. 125 |
| ISSN: | 1879-1344 |
| Popis: | Hyaluronan (HA) was chemically modified to a photocurable derivative by the acylation with a mixed anhydride of trans-cinnamic acid and characterized by UV, IR and 2D NMR spectroscopy. Photocurable HA was processed to a microfibrous structure by wet-spinning technology. Water solubility of otherwise water-soluble HA microfibres was reduced significantly by the solid-state photocrosslinking. We also investigated that the nature of polymer structure had a great impact to a final crosslink ratio. The analysis of the mechanical properties showed higher ultimate tensile strength and increased rigidity of the photocrosslinked fibres in comparison to the untreated ones. Moreover all tested materials are regarded as biocompatible according to the tests of cell viability, phototoxicity and enzymatic degradability, which make them suitable candidates for numerous biomedical applications. |
| Databáze: | OpenAIRE |
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