Antimigration property of a newly designed covered metal stent for esophageal stricture: an in vivo animal study
| Autor: | Hyung-Keun Kim, Young-Seok Cho, Bo-In Lee, Hiun-Suk Chae, Byung-Wook Kim, Sang Woo Kim, Lee-So Maeng, Hwang Choi, Kyu Yong Choi, Sung Soo Kim, Jeong-Seon Ji |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Dogs Esophagus Foreign-Body Migration In vivo medicine Animals Radiology Nuclear Medicine and imaging Animal study Covered stent Esophageal disease business.industry Gastroenterology Stent Equipment Design medicine.disease Surgery medicine.anatomical_structure Esophageal stricture Esophageal Stenosis Stents Histopathology Esophagoscopy business |
| Zdroj: | Gastrointestinal Endoscopy. 74:148-153 |
| ISSN: | 0016-5107 |
| Popis: | Background Covered self-expandable metal stents (SEMSs) are associated with a higher migration rate than uncovered SEMSs. Objective The antimigration property of a novel covered SEMS was investigated in a canine esophageal stricture model. Design The new stent (80 mm in length, 20 or 24 mm in diameter) has multiple protuberances on its body that were designed to be separated from the inner silicone membrane so that they could be embedded into the mucosa after deployment. Twenty-two beagle dogs were subjected to circumferential EMR in the middle esophagus for stricture formation. After 2 weeks, conventional covered stents were inserted in a control group (n = 11), and the newly designed covered SEMSs were inserted in a study group (n = 11). Setting Animal laboratory. Interventions Circumferential EMR of the middle esophagus for stricture formation, followed by endoscopic placement of a conventional or newly designed stent. Main Outcome Measurements Migration, complications, survival, and esophageal histopathology. Results There was no significant difference in the diameter of the esophageal stricture between the control and study groups (10 mm vs 11 mm, P = .52). Within 3 days, all stents in the control group had migrated, whereas 6 had migrated in the study group (100% vs 55%, P = .035). There were no significant complications directly associated with stent insertion. Limitations Complications, survival, and esophageal histopathology could not be compared because all of the conventional stents migrated in the control group within 3 days. Conclusions The newly designed covered SEMS is more resistant to migration than the conventional covered SEMS. |
| Databáze: | OpenAIRE |
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