Thermoresponsive Nanogels of Modified Poly((di(ethylene glycol) methyl ether methacrylate)-co-(2-aminoethyl methacrylate))s
| Autor: | Barbara Trzebicka, Daria Lipowska-Kur, Łukasz Otulakowski, Alicja Utrata-Wesołek, Andrzej Dworak |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Atom-transfer radical-polymerization Comonomer Ether General Chemistry Methacrylate lcsh:QD241-441 chemistry.chemical_compound nanogels lcsh:Organic chemistry chemistry click chemistry Polymer chemistry oligo(ethylene glycol) methacrylate Copolymer Thermoresponsive polymers in chromatography Azide thermoresponsive polymers Ethylene glycol |
| Zdroj: | Polymers, Vol 12, Iss 1645, p 1645 (2020) Polymers Volume 12 Issue 8 |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym12081645 |
| Popis: | A series of copolymers of di(ethylene glycol) methyl ether methacrylate (D) and 2-aminoethyl methacrylate (A) (P(D-co-A)) with variable ratios of comonomers were synthesized using atom transfer radical polymerization. Then, the amino groups of obtained copolymers were modified to clickable azide or prop-2-yn-1-yl carbamate groups. A thermoresponsive copolymers were obtained with the value of cloud point temperature (TCP) dependent on the type and number of functional groups in the copolymer and on the concentration of solutions. For P(D-co-A) copolymers, the TCP increased with increasing content of 2-aminoethyl methacrylate comonomer. The presence of azide and prop-2-yn-1-yl carbamate groups caused the changes of TCP of modified copolymers. All studied copolymers in dilute aqueous solutions aggregated above TCP to nanoparticles with sizes dependent on the solution concentration, heating procedures, and types and numbers of functional groups present in a copolymer chain. The presence of hydrophilic elements in the chain and the increase in the copolymer concentration led to the enlargement of the particle sizes. Aggregates were crosslinked using click reaction between an azide and prop-2-yn-1-yl carbamate groups that led to stable thermoresponsive nanogels. A systematic study of the behavior of copolymers allowed the determination of the chains useful for possible application in drug delivery. |
| Databáze: | OpenAIRE |
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