Portal vein thrombosis related toCassia angustifolia
| Autor: | Ali Erhan Nokay, Secgin Soyuncu, Yildiray Cete |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Senna Plant Senna Cassia angustifolia Toxicology Cassia Humans Medicine Thrombolytic Therapy Treatment Failure Ultrasonography Doppler Color Venous Thrombosis chemistry.chemical_classification biology Traditional medicine Plant Extracts Portal Vein business.industry Anticoagulants Glycoside General Medicine Fabaceae medicine.disease biology.organism_classification Portal vein thrombosis Plant Leaves chemistry Laxatives Female Ultrasonography business |
| Zdroj: | Clinical Toxicology. 46:774-777 |
| ISSN: | 1556-9519 1556-3650 |
| DOI: | 10.1080/15563650701682097 |
| Popis: | Cassia angustifolia (Senna), used as a laxative, is a plant from the Fabaceae family. It includes hydroxyanthracene glycosides, also known as Senna Sennoside. These glycosides stimulate the peristalsis of the colon and alter colonic absorption and secretion resulting in fluid accumulation and expulsion. In the literature, there are reports illustrating the hepatotoxic effects of Cassia angustifolia but there is no report of portal vein thrombosis caused by Cassia Angustifolia.A 42-year-old woman was admitted to the emergency department with a five-day history of worsening epigastric pain, anorexia, episodic vomiting, and intermittent fever. She reported that she had boiled dried senna leaves she had bought from herbalists and drank approximately 200 mL daily for two years. Color Doppler screening found an echogen thrombus obliterating portal vein bifurcation and the right branch. The lumen was obstructed at this level and there was no blood flow through it. Treatment with thrombolytics was unsuccessful.Severe hepatotoxicity senna use is unusual. The cause of senna-related hepatotoxicity is unclear but could be explained by the exposure of the liver to unusual amounts of toxic metabolites of anthraquinone glycosides.Chronic use of Cassia angustifolia may rarely be associated with portal vein thrombosis. |
| Databáze: | OpenAIRE |
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