Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators
| Autor: | Jonathan M. Fitzgerald, Kathleen M. Gura, Brian T. Kalish, Samantha Wang, Hau D. Le, Mark Puder, Kyle J. Seamon, Karsten Gronert |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Physiology medicine.drug_class Administration Oral Pharmacology Biology Anti-inflammatory Inflammation/Immunity/Mediators Liver disease Mice Physiology (medical) Fatty Acids Omega-3 medicine Animals Humans Hepatology Fatty liver Gastroenterology Infant Lipid signaling Lipidome Fish oil medicine.disease Soybean Oil Fatty Liver Parenteral nutrition Immunology Injections Intravenous Emulsions Female Steatosis Inflammation Mediators |
| Zdroj: | American journal of physiology. Gastrointestinal and liver physiology. 305(11) |
| ISSN: | 1522-1547 |
| Popis: | Parenteral nutrition (PN)-associated liver disease (PNALD) is a life-threatening complication of the administration of PN. The development of PNALD may be partly due to the composition of the lipid emulsion administered with PN: soybean oil-based lipid emulsions (SOLE) are associated with liver disease, while fish oil-based lipid emulsions (FOLE) are associated with prevention and improvement of liver disease. The objective of this study was to determine how the choice of lipid emulsion modified the production of bioactive lipid mediators (LMs). We utilized a mouse model of steatosis to study the differential effect of FOLE and SOLE. We subsequently validated these results in serum samples from a small cohort of human infants transitioning from SOLE to FOLE. In mice, FOLE was associated with production of anti-inflammatory, proresolving LMs; SOLE was associated with increased production of inflammatory LMs. In human infants, the transition from SOLE to FOLE was associated with a shift toward a proresolving lipidome. Together, these results demonstrate that the composition of the lipid emulsion directly modifies inflammatory homeostasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|