Secretory carcinoma of the major salivary gland: Provincial population-based analysis of clinical behavior and outcomes
| Autor: | Alena Skálová, Gareth Ayre, Eric Berthelet, Jonn Wu, Martin D. Hyrcza, Tom Thomson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Population Adenocarcinoma Gastroenterology Acinic cell carcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine Major Salivary Gland medicine Humans Registries education Lymph node Retrospective Studies education.field_of_study Salivary gland business.industry Carcinoma Acinar Cell Not Otherwise Specified Carcinoma Middle Aged medicine.disease Salivary Gland Neoplasms Survival Analysis ETV6 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Case-Control Studies Female business Follow-Up Studies |
| Zdroj: | Headneck. 41(5) |
| ISSN: | 1097-0347 |
| Popis: | Background Our aim was to identify the number of cases of secretory carcinoma (SC) of the major salivary gland in a population-based cohort and review its clinical behavior with long-term follow-up. Methods All malignant salivary gland tumors (MSGTs) diagnosed between 1980 and 2014 were assessed for histological features compatible with SC and 140 were selected for further analysis. Results Twenty two new cases of SC were identified, 19 of which were originally classified as acinic cell carcinoma, and 3 as adenocarcinoma, not otherwise specified (NOS). Lymph node involvement was less common in SC tumors (5%) than in the control group (11%). Disease recurrence was seen less frequently in SC (9%) than the control group (20%). Mean disease-free survival was 192 months for SC compared with 162 months for controls (P = 0.15). Conclusion The clinical course of SC is typically indolent with a low risk of relapse not significantly different from other low-grade MSGT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text