Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation
| Autor: | Nazi Lei, Carolin Offenhäuser, Zlatko Kopecki, Rachael Z. Murray, Nadira Ruzehaji, Linda Franken, Allison J. Cowin |
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| Přispěvatelé: | Cowin, Allison J, Lei, Nazi, Franken, Linda, Ruzehaji, Nadria, Offenhäuser, Carolin, Kopecki, Zlatko, Murray, Rachael Z |
| Rok vydání: | 2012 |
| Předmět: |
late endosome
Short Communication cathepsin D Inflammation Biology Cathepsin D Downregulation and upregulation Lysosome medicine Secretion Rab 7 and Stx11 Late endosome integumentary system food and beverages Cell biology secretion medicine.anatomical_structure Immunology lysosome medicine.symptom General Agricultural and Biological Sciences Wound healing Flightless I Gelsolin Intracellular |
| Zdroj: | Communicative & Integrative Biology |
| ISSN: | 1942-0889 |
| DOI: | 10.4161/cib.21928 |
| Popis: | Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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