Clinical relevance of cortical network dynamics in early primary progressive MS
| Autor: | Olga Ciccarelli, Carmen Tur, Claudia Am Gandini Wheeler-Kingshott, Z Khaleeli, Sebastian Ourselin, Ferran Prados, Ahmed T. Toosy, Baris Kanber, Daniel R. Altmann, Arman Eshaghi, Alan J. Thompson |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Computer science Primary Progressive Multiple Sclerosis Primary progressive 03 medical and health sciences 0302 clinical medicine medicine Humans Clinical significance 030304 developmental biology Cerebral Cortex 0303 health sciences Models Statistical Multiple sclerosis Bootstrapping (linguistics) Middle Aged Multiple Sclerosis Chronic Progressive Covariance medicine.disease Magnetic Resonance Imaging Neurology Cortical network Disease Progression Female Neurology (clinical) Nerve Net Neuroscience 030217 neurology & neurosurgery Follow-Up Studies |
| ISSN: | 1352-4585 |
| Popis: | Background: Structural cortical networks (SCNs) reflect the covariance between the cortical thickness of different brain regions, which may share common functions and a common developmental evolution. SCNs appear abnormal in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, but have never been assessed in primary progressive multiple sclerosis (PPMS). Objective: The aim of this study was to test whether SCNs are abnormal in early PPMS and change over 5 years, and correlate with disability worsening. Methods: A total of 29 PPMS patients and 13 healthy controls underwent clinical and brain magnetic resonance imaging (MRI) assessments for 5 years. Baseline and 5-year follow-up cortical thickness values were obtained and used to build correlation matrices, considered as weighted graphs to obtain network metrics. Bootstrap-based statistics assessed SCN differences between patients and controls and between patients with fast and slow progression. Results: At baseline, patients showed features of lower connectivity ( p = 0.02) and efficiency ( p Conclusion: SCNs are abnormal in early PPMS. Longitudinal SCN changes demonstrated a switch from low- to high-efficiency networks especially among fast progressors, indicating their clinical relevance. |
| Databáze: | OpenAIRE |
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