Effect of amiodarone on serum quinidine and procainamide levels
| Autor: | Jeffrey A. Werner, A.Kim Saal, Ellen L. Graham, H. Leon Greene, Gena K. Sears |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Quinidine medicine.medical_specialty Dose medicine.medical_treatment Amiodarone Procainamide Internal medicine Humans Medicine Drug Interactions Prospective Studies Aged Benzofurans Chemotherapy business.industry Arrhythmias Cardiac Middle Aged Drug interaction Regimen Endocrinology Toxicity Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 53:1264-1267 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(84)90076-6 |
| Popis: | Serum levels of quinidine or procainamide were measured in patients who had amiodarone added to their antiarrhythmic regimen. Dosages of quinidine or procainamide were held constant. Eleven of 11 patients had an increase in the serum quinidine level, and 11 of 12 other patients had an increase in the serum procainamide level. The dose requirement to maintain a stable plasma level of quinidine or procainamide decreased by 37% and 20%, respectively. Clinical toxicity occasionally occurred with the increase in serum levels of quinidine and procainamide, and the dose of these drugs should be decreased when amiodarone is administered concurrently. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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