Estimating the Timing of Mother-to-Child Transmission of Human Immunodeficiency Virus in a Breast-Feeding Population in Kinshasa, Zaire
| Autor: | T C Quinn, Chris Brown, Chin-Yih Ou, Manzila Tarande, Jeanne Bertolli, Munkolenkole Kamenga, Michael E. St. Louis, Phillip Nieburg, R. J. Simonds |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Time Factors Population Breastfeeding HIV Infections Acquired immunodeficiency syndrome (AIDS) Pregnancy Humans Immunology and Allergy Medicine Childbirth Prospective Studies Risk factor education reproductive and urinary physiology education.field_of_study business.industry Obstetrics Infant Newborn Infant medicine.disease Infectious Disease Transmission Vertical Surgery Breast Feeding Infectious Diseases Democratic Republic of the Congo Female business Breast feeding Postpartum period |
| Zdroj: | Journal of Infectious Diseases. 174:722-726 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Breast-fed infants born to human immunodeficiency virus (HIV)-infected mothers in Kinshasa, Zaire, were monitored a mean of 18 months. HIV infection in infants was determined by polymerase chain reaction (PCR), HIV culture, or ELISA. PCR test results for HIV DNA on venous blood drawn from children ages 0-2 days and 3-5 months were used to estimate proportions of mother-to-child transmission and transmission risks during the intrauterine, intrapartum/early postpartum, and late postpartum periods. Among 69 HIV-infected children (26% of the cohort), 23% (95% confidence interval [CI], 14%-35%) were estimated to have had intrauterine, 65% (CI, 53%-76%) intrapartum/early postpartum, and 12% (CI, 5%-22%) late postpartum transmission. The estimated risks for intrauterine, intrapartum/early postpartum, and late postpartum infection, respectively, were 6% (16/261; CI, 4%-10%), 18% (45/245; CI, 14%-24%), and 4% (8/189; CI, 2%-8%). These results support earlier studies indicating that most transmission occurs during labor and delivery or in the early postpartum period and that the risk of HIV transmission through breast-feeding during the postpartum period is substantial. |
| Databáze: | OpenAIRE |
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