The use of in vivo confocal microscopy to track treatment success in fungal keratitis and to differentiate between Fusarium and Aspergillus keratitis

Autor: Seyed Ali Tabatabaei, Amir Houshang Beheshtnejad, Mohammad Soleimani, Shahram Mahmoudi, Niloufar Valipour, Seyed Mehdi Tabatabaei
Rok vydání: 2019
Předmět:
Zdroj: International Ophthalmology. 40:483-491
ISSN: 1573-2630
0165-5701
DOI: 10.1007/s10792-019-01209-2
Popis: To evaluate the usefulness of serial in vivo confocal microscopy (IVCM) examinations to measure hyphal density for monitoring the treatment success among patients with fungal keratitis, and to compare the hyphal diameter as well as branching angle as a way of differentiation between Aspergillus and Fusarium species observed in IVCM. Prospective nonrandomized study. The study was conducted from February 2015 to September 2016. Hyphal diameter, density and branching angle measurements were performed using IVCM at admission and on a weekly basis for at least 2 weeks after the start of treatment. During the period of study, 65 patients with culture-confirmed fungal keratitis were recruited. Of them, 40 were culture-positive for Fusarium spp. and 25 patients for Aspergillus spp. Before the start of treatment, the mean branching angle did not differ between the two species and the mean hyphal diameter was statistically higher for Aspergillus spp. (p = 0.029). Two weeks after the start of treatment, the mean hyphal diameter was statistically lower (p
Databáze: OpenAIRE
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