Glucocorticoid receptors in lymphocytes and stability of kidney graft function

Autor: R Blagojevic, Mojca Vulovic, Zorica Zakula, Nevena Ribarac-Stepic, L Djukanovic, Esma R. Isenovic, Goran Koricanac, R Naumovic
Rok vydání: 2001
Předmět:
Adult
Graft Rejection
Male
lymphocytes
medicine.medical_specialty
In Vitro Techniques
Biology
Dexamethasone
General Biochemistry
Genetics and Molecular Biology
Organ transplantation
03 medical and health sciences
Cytosol
Receptors
Glucocorticoid
0302 clinical medicine
Glucocorticoid receptor
Internal medicine
glucocorticoid resistance
medicine
Humans
Lymphocytes
Receptor
Kidney transplantation
030304 developmental biology
Cell Nucleus
0303 health sciences
Kidney
Hematology
organ transplantation
downregulation
glucocorticoid receptors
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Transplantation
Kinetics
surgical procedures
operative
medicine.anatomical_structure
Endocrinology
Case-Control Studies
030220 oncology & carcinogenesis
Female
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Zdroj: Clinical and Experimental Medicine
ISSN: 1591-8890
DOI: 10.1007/s102380100001
Popis: The glucocorticoid receptors in lymphocytes of patients treated with glucocorticoids after kidney transplantation have been studied in order to determine whether abnormalities in corticosteroid binding and trans-activation of steroid-receptor complexes, i.e., their translocation into nuclei, may contribute to the resistance of patients to glucocorticoid therapy. The patients were divided into two groups, according to graft stability: patients with stable graft function and those with chronic allograft rejection. The study revealed changes in both level and binding affinity of glucocorticoid receptors in peripheral blood lymphocytes from patients with chronic graft rejection, compared with control level, as well as with values of patients with stable graft function. These data indicate that sensitivity to glucocorticoids depends, at least in part, on the alterations of glucocorticoid receptors. The receptor translocation into nuclei indicates that unknown post-receptor events might also be involved in glucocorticoid resistance that seriously impair successive glucocorticoid therapy after organ transplantation. Further examination of glucocorticoid receptors in cases of organ transplantation seems warranted.
Databáze: OpenAIRE
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