Assessment of axonal sprouting and motor performance after hypoglossal-facial end-to-side nerve repair: experimental study in rats
| Autor: | Rahime Sekerci, Arzu Hizay, Yasemin Behram Kandemir, Umut Ozsoy, Doychin N. Angelov, Levent Sarikcioglu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Hypoglossal Nerve Facial Muscles 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Tongue medicine.artery Medicine Animals 0501 psychology and cognitive sciences Rats Wistar Nerve repair Facial Nerve Injuries business.industry General Neuroscience 05 social sciences Abdominal aorta Anastomosis Surgical Anatomy Recovery of Function Plastic Surgery Procedures Facial nerve Axons Axonal sprouting Rats Disease Models Animal medicine.anatomical_structure Vibrissae Female business Hypoglossal nerve 030217 neurology & neurosurgery End to side anastomosis Reinnervation |
| Zdroj: | Experimental brain research. 238(6) |
| ISSN: | 1432-1106 |
| Popis: | Hypoglossal–facial nerve anastomosis (HFA) aims to reanimate denervated mimic muscles with hypoglossal axons when the transected facial nerve is not accessible. The aim of this study was to evaluate the recovery of HFA using a “Y” tube in two variants: (1) the proximal stump of the hypoglossal nerve was entubulated to the “Y” tube (classic “Y” tube HFA) and (2) the “Y” tube was sutured to an epineurial window of a slightly damaged hypoglossal nerve (end-to-side “Y” tube HFA). A total of 48 adult female rats were divided into four groups: intact controls (group 1), sham operated (group 2), classic “Y” tube HFA (group 3) and end-to-side “Y” tube HFA (group 4). The abdominal aorta with both common iliac arteries of isogeneic male rats served as the Y-tube conduit. Animals from group 4 recovered better than those from group 3: the degree of collateral axonal branching (3 ± 1%) was significantly lower than that determined in group 3 (13 ± 1%). The mean deviation of the tongue from the midline was significantly smaller in group 4 (6 ± 4°) than that measured in animals from group 3 (41 ± 6°). In the determination of vibrissal motor function in group 3 and group 4, a decrease in amplitude was found to be − 66% and − 92%, respectively. No differences in the reinnervation pattern of the target muscles were detected. As a result, these surgical models were not determined to be able to improve vibrissal movements. It was concluded that performance of end-to-side “Y” tube HFA diminishes collateral axonal branching at the lesion site, which in turn, promotes better recovery of tongue- and vibrissal-motor performance. |
| Databáze: | OpenAIRE |
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