Synthesis and structure–activity relationship of benzetimide derivatives as human CXCR3 antagonists

Autor:	Mieke Buntinx, Jean Pierre Frans Van Wauwe, Erwin Coesemans, Jean-Pierre André Marc Bongartz, Guy Van Lommen, Bart Hermans
Rok vydání:	2008
Předmět:	Receptors CXCR3 Stereochemistry Clinical Biochemistry BENZETIMIDE Pharmaceutical Science CXCR3 Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound stomatognathic system immune system diseases Drug Discovery Humans Structure–activity relationship skin and connective tissue diseases Imide Molecular Biology Dexetimide Organic Chemistry hemic and immune systems stomatognathic diseases chemistry Molecular Medicine Pharmacophore Antagonism
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:5819-5823
ISSN:	0960-894X
Popis:	The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-cholinergic activity and identification of the key pharmacophore moieties of the series.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5814c4481e3ca2d821280a7b6e4d1ef https://doi.org/10.1016/j.bmcl.2008.07.115 Zobrazit plný text záznamu Full Text from ScienceDirect