A Compressive Review about Taxol®: History and Future Challenges
| Autor: | Gema Lozano-Terol, Manuel Canovas-Diaz, Rosa A Sola-Martinez, Teresa de Diego Puente, Julia Gallego-Jara |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Paclitaxel Microtubule dynamics media_common.quotation_subject Pharmaceutical Science Apoptosis Review Bioinformatics Mitotic arrest Microtubules Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Neoplasms Drug Discovery cancer Humans Medicine Physical and Theoretical Chemistry 030304 developmental biology media_common Antitumor activity 0303 health sciences business.industry Organic Chemistry drug Antineoplastic Agents Phytogenic cell death chemistry Drug Resistance Neoplasm Chemistry (miscellaneous) antitumor agent 030220 oncology & carcinogenesis M Phase Cell Cycle Checkpoints Molecular Medicine Taxus Sustainable production business biotechnology |
| Zdroj: | Molecules Molecules, Vol 25, Iss 5986, p 5986 (2020) |
| ISSN: | 1420-3049 |
| Popis: | Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely employed antitumoral drugs. Taxol® was the first microtubule targeting agent described in the literature, with its main mechanism of action consisting of the disruption of microtubule dynamics, thus inducing mitotic arrest and cell death. However, secondary mechanisms for achieving apoptosis have also been demonstrated. Despite its wide use, Taxol® has certain disadvantages. The main challenges facing Taxol® are the need to find an environmentally sustainable production method based on the use of microorganisms, increase its bioavailability without exerting adverse effects on the health of patients and minimize the resistance presented by a high percentage of cells treated with paclitaxel. This review details, in a succinct manner, the main aspects of this important drug, from its discovery to the present day. We highlight the main challenges that must be faced in the coming years, in order to increase the effectiveness of Taxol® as an anticancer agent. |
| Databáze: | OpenAIRE |
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