Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study
Autor: | Manyan Fung, Xiaoqing Xue, Andrew Szilagyi |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Population Prevalence Ethnic group 030209 endocrinology & metabolism Canadian census data Disease epidemiology Lactase nonpersistent Lactase persistent 03 medical and health sciences 0302 clinical medicine Immigration policy education AcademicSubjects/MED00260 education.field_of_study Human migration business.industry Lactose intolerance Original Articles Census Confidence interval Demographic inference Lactase persistence 030104 developmental biology Geography business Demography |
Zdroj: | Journal of the Canadian Association of Gastroenterology |
ISSN: | 2515-2092 |
Popis: | Objectives The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%–74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level. Methods We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated. Results The national LNP rate is estimated at 44% (CI 41%–47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively. Conclusion Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic. |
Databáze: | OpenAIRE |
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