Diversity of PEGylation methods of liposomes and their influence on RNA delivery
| Autor: | O. O. Koloskova, Dmitry Kudlay, V. V. Smirnov, Musa Khaitov, A A Nikonova, V A Simonova, A S Nosova |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Liposome 010405 organic chemistry Chemistry Genetic enhancement Organic Chemistry Pharmaceutical Science Transfection 01 natural sciences Biochemistry In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry In vivo Drug Discovery PEG ratio Nucleic acid PEGylation Biophysics Molecular Medicine |
| Popis: | Gene therapy is a promising approach for personalized medicine, but its application in humans requires development of efficient and safe vehicles. PEGylated liposomes are some of the most suitable delivery systems for nucleic acids because of their stability under physiological conditions and prolonged circulation time, compared to conventional and other types of "stealth" liposomes. In vitro/in vivo activity of PEGylated liposomes is highly dependent on PEG motif abundance. The process of "stealth" coverage formation is a very important parameter for efficient transfection assays and further fate determination of the PEG layer after tissue penetration. In this review, we discuss the latest methods of PEGylated liposome preparation. |
| Databáze: | OpenAIRE |
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