DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas
| Autor: | Andrew J. Holcomb, Rashna Madan, Yelizaveta Shnayder, Sufi M. Thomas, Laura E Brown, Ossama Tawfik, Nicholas A. Wallace |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male DNA Repair Microarray DNA repair Papillomavirus E7 Proteins Cell Alphapapillomavirus Biology Article 03 medical and health sciences Replication Protein A Virology Gene expression DNA Repair Protein medicine Humans Head and neck Aged 030304 developmental biology 0303 health sciences Oncogene BRCA1 Protein Squamous Cell Carcinoma of Head and Neck Papillomavirus Infections 030302 biochemistry & molecular biology virus diseases Middle Aged female genital diseases and pregnancy complications medicine.anatomical_structure Ubiquitin-Conjugating Enzymes Cancer research Immunohistochemistry Female |
| Zdroj: | Virology |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2020.07.004 |
| Popis: | The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV (HPV– HNSCCs), HPV + HNSCCs are more responsive to therapy and associated with better oncologic outcomes. As a result, the HPV status of an HNSCC is an important determinant in medical management. One method to determine the HPV status of an HNSCC is increased expression of p16 caused by the HPV E7 oncogene. We identified novel expression changes in HPV + HNSCCs. A comparison of gene expression among HPV+ and HPV- HNSCCs in The Cancer Genome Atlas demonstrated increased DNA repair gene expression in HPV + HNSCCs. Further, DNA repair gene expression correlated with HNSCC survival. Immunohistochemical analysis of a novel HNSCC microarray confirmed that DNA repair protein abundance is elevated in HPV + HNSCCs. |
| Databáze: | OpenAIRE |
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