INHIBITORY EFFECT OF METYRAPONE ON GLUCOSE UTILIZATION BY BRAIN AND MUSCLE AND ON INSULIN RELEASE BY THE PANCREAS
| Autor: | Patricia Metzger, Oscar D Bruno, Willy Malaisse |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Glucose utilization Endocrinology Diabetes and Metabolism medicine.medical_treatment In Vitro Techniques Endocrinology Internal medicine Insulin Secretion medicine Animals Insulin Pancreas Inhibitory effect Metyrapone Chemistry Muscles Brain General Medicine Rats Glucose medicine.anatomical_structure Depression Chemical Female Oxidation-Reduction medicine.drug |
| Zdroj: | Acta Endocrinologica. 70:710-718 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0700710 |
| Popis: | The effect of metyrapone on in vitro glucose metabolism in the rat muscle and brain, and on insulin secretion by the rat pancreas was investigated. In the presence of increasing concentrations of metyrapone ditartrate, there was a significant progressive reduction in glucose uptake by incubated hemidiaphragms and in the glucose uptake and oxidation by incubated brain pieces. The insulin output by incubated pieces of pancreas was also significantly inhibited by metyrapone ditartrate. A clear dose-action relationship is shown between the residual glucose uptake by the muscle and the uptake or oxidation of glucose by the brain on one hand, and the logarithm of the corresponding metyrapone ditartrate concentration on the other. These data may help to explain some clinical and experimental findings, i. e. the simultaneous occurrence of hyperglycaemia, signs of cerebral dysfunction and also of growth hormone release after the administration of metyrapone in vivo. |
| Databáze: | OpenAIRE |
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