Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
| Autor: | Steven G. Shimada, J. G. Collins, Kelly A. Shimada |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Mepyramine Mice Inbred Strains Histamine H1 receptor Mice chemistry.chemical_compound Internal medicine medicine Animals Receptor PAR-2 skin and connective tissue diseases Pyrilamine Receptor Pharmacology Behavior Animal integumentary system Pruritus Antagonist Scratching eye diseases Endocrinology chemistry Histamine H1 Antagonists Oligopeptides Histamine medicine.drug |
| Zdroj: | European Journal of Pharmacology. 530:281-283 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2005.11.012 |
| Popis: | We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 microg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch. |
| Databáze: | OpenAIRE |
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