Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate

Autor: Eric Zimmermann, Catherine Durand, Pascal Chanez, Léa Touri, Nicolas Molinari, Lara Leclerc, Véronique Chamel Mossuz, Marcelline Gaude-Môme, Michel Klerlein, Isabelle Vachier, Muriel Dubosson, Caroline Marie-Desvergne
Přispěvatelé: NanoSafety Platform (NPS), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA) - Grenoble, Université Grenoble Alpes (UGA), Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Laboratoire de psychologie expérimentale (LPE - UMR8581), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-École pratique des hautes études (EPHE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Médecine Respiratoire [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Breath Research
Journal of Breath Research, IOP Science, 2016, 10 (3), pp.036006. ⟨10.1088/1752-7155/10/3/036006⟩
Journal of Breath Research, 2016, 10 (3), pp.036006. ⟨10.1088/1752-7155/10/3/036006⟩
ISSN: 1752-7155
1752-7163
DOI: 10.1088/1752-7155/10/3/036006⟩
Popis: International audience; Aircraft engine exhaust increases the number concentration of nanoparticles (NP) in the surrounding environment. Health concerns related to NP raise the question of the exposure and health monitoring of airport workers. No biological monitoring study on this profession has been reported to date. The aim was to evaluate the NP and metal exposure of airport workers using exhaled breath condensate (EBC) as a non-invasive biological matrix representative of the respiratory tract. EBC was collected from 458 French airport workers working either on the apron or in the offices. NP exposure was characterized using particle number concentration (PNC) and size distribution. EBC particles were analyzed using dynamic light scattering (DLS) and scanning electron microscopy coupled to x-ray spectroscopy (SEM-EDS). Multi-elemental analysis was performed for aluminum (Al), cadmium (Cd) and chromium (Cr) EBC contents. Apron workers were exposed to higher PNC than administrative workers (p < 0.001). Workers were exposed to very low particle sizes, the apron group being exposed to even smaller NP than the administrative group (p < 0.001). The particulate content of EBC was brought out by DLS and confirmed with SEM-EDS, although no difference was found between the two study groups. Cd concentrations were higher in the apron workers (p < 0.001), but still remained very low and close to the detection limit. Our study reported the particulate and metal content of airport workers airways. EBC is a potential useful tool for the non-invasive monitoring of workers exposed to NP and metals.
Databáze: OpenAIRE
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