Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent

Autor:	Nak Doo Kim, Lee Bong Yong, Jong Wook Lee
Rok vydání:	2001
Předmět:	Antioxidant Cytochrome biology Pyrazine Chemistry medicine.medical_treatment Organic Chemistry Cancer DABCO CYP2E1 medicine.disease chemistry.chemical_compound Neoplasms Pyrazines Drug Discovery biology.protein medicine Molecular Medicine Organic chemistry Anticarcinogenic Agents Enzyme Inhibitors Carcinogen Octane
Zdroj:	Archives of pharmacal research. 24(1)
ISSN:	0253-6269
Popis:	2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase II enzymes involved in the detoxification of carcinogens. A practical preparation method of 2-(allylthio) pyrazine derivatives was established by the reaction of 2-mercaptopyrazine and allylbromides in the presence of a catalytic antioxidant, DABCO (1,4-diazabicyclo[2,2,2] octane), in dimethylformamide at below 50 degrees C.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51dc70541573a6a481ed88453b270dd https://pubmed.ncbi.nlm.nih.gov/11235806 Zobrazit plný text záznamu Full text from SpringerLink