The use of immobilized enzymes in organic synthesis. Part 6. Oxidation of 1-alkyl-3-carbamoylpyridinium chlorides by rabbit liver aldehyde oxidase

Autor:	F. Muller, D. J. Buurman, S.A.G.F. Angelino, H. C. Van Der Plas
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Immobilized enzyme Single product Organic Chemistry Rabbit (nuclear engineering) General Chemistry Organische Chemie chemistry.chemical_compound Enzyme chemistry Life Science Organic chemistry heterocyclic compounds Organic synthesis Aldehyde oxidase Alkyl
Zdroj:	Recueil des travaux chimiques des Pays-Bas = Journal of the Royal Netherlands Chemical Society, 101, 342-346 Recueil des travaux chimiques des Pays-Bas = Journal of the Royal Netherlands Chemical Society 101 (1982)
ISSN:	0165-0513
DOI:	10.1002/recl.19821011005
Popis:	A method is described for the oxidation of some 1-alkyl-3-carbamoylpyridinium chlorides by reaction with immobilized rabbit liver aldehyde oxidase. With the 1-methyl-, 1-ethyl-and 1-n-propyl derivatives, only the 1-alkyl-1,6-dihydro-6-oxo-3-pyridinecarboxamides have been obtained, but with the t-Bu analogue the corresponding 4-oxo compound was found as single product. The i-Pr derivative gave rise to a mixture of the corresponding 4- and 6-oxo compounds. From the kinetic data some information has been acquired with respect to the enzyme active-site environment and the binding of the substrates to the enzyme.
Databáze:	OpenAIRE
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