Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1
| Autor: | Deng-Ke Li, Jing Chen, Zhen-Zhen Ge, Zhen-Xiao Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Polygonum Article Subject education Pharmacology 03 medical and health sciences 0302 clinical medicine Oral administration medicine Liver injury Aqueous extract biology Activity inhibition business.industry CYP1A2 lcsh:Other systems of medicine CYP2E1 lcsh:RZ201-999 medicine.disease biology.organism_classification 030104 developmental biology Complementary and alternative medicine 030220 oncology & carcinogenesis business Serum transaminase |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017) |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2017/9456785 |
| Popis: | The objective of this study is to investigate the relationship between the hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root of Polygonum multiflorum Thunb., He Shou Wu) and the activity of CYP1A2 or CYP2E1 in the rat liver. Levels of rat serum transaminases ALT and AST were not altered but the activity of CYP1A2 or CYP2E1 in the rat liver was significantly inhibited after oral administration of aqueous extract of PMR under the experimental dosage. However, levels of ALT and AST were significantly increased and the activity of CYP1A2 or CYP2E1 was significantly decreased after injection of specific inhibitor for CYP1A2 or CYP2E1 combined with oral administration of aqueous extract of PMR, especially under the repeated treatment over interval times. Liver histopathological observation showed that a moderate liver injury occurred in rats receiving PMR treatment with the activity of CYP1A2 or CYP2E1 inhibited, but there was no significant liver damage in rats receiving PMR treatment or CYP inhibitor alone. These suggested that low level activity of CYP1A2 or CYP2E1 from genetic polymorphism among people might be one of the important reasons for the hepatotoxicity induced by PMR in clinical practice. |
| Databáze: | OpenAIRE |
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