Assessment of CD8+ T cell immune activation markers to monitor response to antiretroviral therapy among HIV-1 infected patients in Côte d’Ivoire
| Autor: | Pascale Ondoa, Marie-Yolande Borget, Luc Kestens, Monica Nolan, John N. Nkengasong, Stephania Koblavi-Deme |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male T cell Immunology HIV Infections CD8-Positive T-Lymphocytes CD38 Biology Cohort Studies Immune system Antigen Antigens CD Antiretroviral Therapy Highly Active Immunopathology Clinical Studies medicine Humans Immunology and Allergy Cytotoxic T cell ADP-ribosyl Cyclase Membrane Glycoproteins HLA-DR Antigens Viral Load ADP-ribosyl Cyclase 1 Virology Treatment Outcome medicine.anatomical_structure ROC Curve Area Under Curve HIV-1 Female Viral load Biomarkers CD8 |
| Zdroj: | Clinical and experimental immunology |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2005.02734.x |
| Popis: | Summary Because of the paucity of plasma HIV RNA viral load (VL) tests in resource-poor settings, the CD4+ T cell count is often used as the sole laboratory marker to evaluate the effectiveness of antiretroviral therapy (ART) in HIV-infected patients. In untreated patients, the level of activated T cells is positively correlated with VL and represents a prognostic marker of HIV infection. However, little is known about its value to predict early drug failure, taking into account the relatively high non-specific immune activation background observed in many resource-limited tropical countries. We assessed the use of immune activation markers (expression of CD38 and/or human leucocyte antigen-DR on CD8+ lymphocytes) to predict virological response to ART in a cohort of HIV-1 infected patients in Abidjan, Côte d’Ivoire. Correlations between VL, absolute CD4+ T cell counts and immune activation levels were examined in 111 HIV patient samples at baseline and after 6 and 12 months of therapy. The percentage of CD38+ CD8+ T cells appeared to be the best correlate of VL. In contrast, changes in CD4+ T cell counts provided a poor correlate of virological response to ART. Unfortunately, CD38+ CD8+ percentages lacked specificity for the determination of early virological drug failure and did not appear to be reliable surrogates of RNA viral load. CD38+ CD8+ T cell percentages may, rather, provide a sensitive estimate of the overall immune recovery, and be a useful extra laboratory parameter to CD4 counts that would contribute to improve the clinical management of HIV-infected people when VL testing facilities are lacking. |
| Databáze: | OpenAIRE |
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