Oncologic and functional outcomes of salvage supracricoid partial laryngectomy

Autor:	Won Shik Kim, Yoon Woo Koh, Eun Chang Choi, Se-Heon Kim, Ji Hoon Kim, Hyung Kwon Byeon
Rok vydání:	2018
Předmět:	Adult Male China medicine.medical_specialty Laryngectomy Kaplan-Meier Estimate Cancer Care Facilities Disease-Free Survival Cricoid Cartilage Cohort Studies 03 medical and health sciences 0302 clinical medicine Quality of life otorhinolaryngologic diseases medicine Humans Neoplasm Invasiveness 030223 otorhinolaryngology Laryngeal Neoplasms Partial laryngectomy Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Salvage Therapy business.industry fungi food and beverages General Medicine Middle Aged Survival Analysis Dysphagia Recurrent Laryngeal Carcinoma Surgery Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Quality of Life Female Salvage surgery medicine.symptom business Follow-Up Studies
Zdroj:	Acta Oto-Laryngologica. 138:1117-1122
ISSN:	1651-2251 0001-6489
DOI:	10.1080/00016489.2018.1506154
Popis:	Supracricoid partial laryngectomy (SCL) can have a positive impact on patients' quality of life by circumventing dysphagia and voice problems resulting from creation of a permanent stoma after conventional total laryngectomy (TL) surgery.The aim of this study was to investigate the oncologic and functional outcomes of salvage SCL for recurrent laryngeal carcinoma.Forty-five patients that underwent salvage surgery for recurrent laryngeal carcinoma between January 2004 and May 2015 after initial treatment failure were included in this retrospective study.Overall survival and disease free survival were non-significantly higher in the salvage SCL group (n = 14) than in the salvage TL group (n = 31) (87.5 versus 56.5%, 53.4 versus 41.9%). Multivariate analyses showed only positive resection margin to be significantly associated with survival and recurrence (HR 9.974, p = .007, and HR 9.196, p = .002, respectively). In the salvage SCL group, 92.8% achieved successful decannulation and all patients returned to an oral diet. All patients in the salvage TL group sustained a permanent stoma and conversation was possible only through esophageal voice or a voice prosthesis. 74.2% of patients in the group were able to tolerate an oral diet.Salvage SCL showed comparable oncologic outcomes and favorable functional outcomes relative to the classic salvage TL. This study could provide a sufficient basis of SCL as salvage treatment for recurrent laryngeal carcinoma in selected patients.
Databáze:	OpenAIRE
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